Hirokazu Kanegane Selected Research

X-Linked Syndrome Enteropathy Polyendocrinopathy Immune Dysregulation

1/2022	A case of autoimmune enteropathy with CTLA4 haploinsufficiency.
11/2019	Hematopoietic stem cell transplantation recovers insulin deficiency in type 1 diabetes mellitus associated with IPEX syndrome.
1/2019	Identification of autoantibodies using human proteome microarrays in patients with IPEX syndrome.
2/2014	Selective expansion of donor-derived regulatory T cells after allogeneic bone marrow transplantation in a patient with IPEX syndrome.
6/2009	Minimal change nephrotic syndrome associated with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.

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Hirokazu Kanegane Research Topics

Disease

20	Infections 01/2022 - 08/2002
16	Bruton type agammaglobulinemia 02/2016 - 04/2002
12	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 01/2022 - 10/2002
11	Agammaglobulinemia (Hypogammaglobulinemia) 01/2020 - 09/2002
10	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 01/2022 - 02/2005
10	Primary Immunodeficiency Diseases 01/2021 - 06/2005
9	Neoplasms (Cancer) 03/2022 - 12/2002
8	Leukemia 06/2018 - 01/2009
7	Epstein-Barr Virus Infections 11/2018 - 12/2002
6	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 04/2022 - 01/2017
6	2 X-Linked Lymphoproliferative Syndrome 01/2022 - 06/2012
5	Inflammation (Inflammations) 06/2022 - 06/2009
5	Fever (Fevers) 06/2022 - 06/2009
5	X-Linked Syndrome Enteropathy Polyendocrinopathy Immune Dysregulation 01/2022 - 06/2009
5	Common Variable Immunodeficiency 01/2021 - 04/2008
5	Hemorrhage 01/2019 - 03/2008
5	Bacterial Infections (Bacterial Infection) 12/2008 - 09/2002
4	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 10/2022 - 11/2004
4	Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell) 01/2020 - 05/2010
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 06/2018 - 10/2010
4	Down Syndrome (Down's Syndrome) 05/2017 - 05/2008
4	Infectious Mononucleosis (Glandular Fever) 06/2010 - 01/2004
3	Pneumonia (Pneumonitis) 10/2022 - 12/2021
3	Splenomegaly 01/2022 - 12/2009
3	Diarrhea 01/2022 - 08/2013
3	Dysbiosis 11/2021 - 01/2021
3	Bacteremia 11/2020 - 01/2007
3	Autoimmune Diseases (Autoimmune Disease) 01/2020 - 10/2018
3	Respiratory Insufficiency (Respiratory Failure) 05/2018 - 08/2014
3	Hemolytic-Uremic Syndrome 06/2015 - 12/2012
3	Residual Neoplasm 04/2014 - 02/2010
3	Neutropenia 03/2009 - 09/2005
2	COVID-19 10/2022 - 03/2022
2	Hyperferritinemia 06/2022 - 07/2014
2	Immune System Diseases (Immune Disorders) 03/2022 - 02/2004
2	Rare Diseases (Rare Disease) 01/2022 - 01/2018
2	Autoimmune enteropathy 01/2022 - 06/2009
2	Bronchiolitis Obliterans Syndrome 12/2021 - 01/2018
2	Job Syndrome (Hyper-IgE Syndrome) 01/2021 - 01/2020
2	Reinfection 01/2020 - 02/2004
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 11/2019 - 06/2009
2	Pancytopenia 01/2019 - 01/2019
2	Virus Diseases (Viral Diseases) 11/2018 - 12/2006
2	Pulmonary Alveolar Proteinosis 05/2018 - 01/2018
2	Disease Progression 01/2018 - 02/2015
2	X-Linked Combined Immunodeficiency Diseases (X Linked Severe Combined Immunodeficiency) 10/2017 - 02/2004
2	Hypergammaglobulinemia (Hyperimmunoglobulinemia) 10/2017 - 05/2003
2	Hematologic Neoplasms (Hematological Malignancy) 05/2017 - 04/2014
2	Central Nervous System Diseases (CNS Diseases) 06/2015 - 10/2013
2	Brain Diseases (Brain Disorder) 06/2015 - 12/2012
2	Lymphoma (Lymphomas) 04/2014 - 01/2011
2	IGA Glomerulonephritis (IGA Nephropathy) 01/2014 - 03/2004
2	Thrombocytopenia 1 01/2014 - 02/2013
2	Wiskott-Aldrich Syndrome 02/2013 - 11/2006
2	Anemia 11/2012 - 05/2003
2	Hereditary Spherocytosis 09/2012 - 12/2006
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/2010 - 10/2005
2	Vasculitis (Vasculitides) 06/2009 - 02/2005
2	Sepsis (Septicemia) 06/2009 - 09/2005

Drug/Important Bio-Agent (IBA)

20	Immunoglobulins (Immunoglobulin)IBA 11/2020 - 03/2002
15	Agammaglobulinaemia Tyrosine KinaseIBA 01/2020 - 04/2002
12	Proteins (Proteins, Gene)FDA Link 01/2020 - 11/2002
9	CytokinesIBA 01/2020 - 07/2008
7	Intravenous Immunoglobulins (IVIG)FDA Link 06/2022 - 08/2002
6	AutoantibodiesIBA 10/2022 - 01/2009
6	X-Linked Inhibitor of Apoptosis ProteinIBA 01/2022 - 06/2012
4	Anti-Bacterial Agents (Antibiotics)IBA 11/2020 - 03/2009
4	Immunoglobulin E (IgE)IBA 01/2020 - 06/2009
4	Immunoglobulin G (IgG)IBA 11/2018 - 01/2004
4	Signaling Lymphocytic Activation Molecule Associated ProteinIBA 01/2017 - 10/2002
3	SteroidsIBA 04/2022 - 02/2005
3	RNA (Ribonucleic Acid)IBA 11/2021 - 12/2009
3	Busulfan (Busulfex)FDA Link 01/2021 - 05/2017
3	EnzymesIBA 04/2019 - 06/2015
3	Immunoglobulin A (IgA)IBA 04/2015 - 03/2004
3	Transcription Factors (Transcription Factor)IBA 10/2010 - 10/2002
2	Interferon Type IIBA 10/2022 - 03/2022
2	Infliximab (Remicade)FDA Link 06/2022 - 06/2009
2	AntigensIBA 01/2022 - 12/2009
2	InterferonsIBA 01/2022 - 12/2006
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 11/2021 - 12/2012
2	veltuzumabIBA 01/2021 - 01/2020
2	VaccinesIBA 11/2020 - 01/2019
2	I-kappa B KinaseIBA 01/2020 - 11/2018
2	Growth Hormone (Somatotropin)IBA 01/2020 - 03/2006
2	Surface-Active Agents (Surfactants)IBA 05/2018 - 01/2018
2	Immunoglobulin IsotypesIBA 03/2015 - 01/2006
2	Meropenem (Merrem)FDA LinkGeneric 01/2014 - 01/2007
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 05/2013 - 12/2009
2	AntibodiesIBA 04/2013 - 01/2004
2	Epstein-Barr Virus Nuclear AntigensIBA 12/2009 - 01/2004

Therapy/Procedure

30	Therapeutics 06/2022 - 08/2002
14	Hematopoietic Stem Cell Transplantation 12/2021 - 09/2011
9	Cell Transplantation 10/2022 - 02/2013
7	Drug Therapy (Chemotherapy) 01/2019 - 03/2008
5	Transplantation 04/2019 - 04/2003
4	Stem Cell Transplantation 12/2021 - 11/2006
4	Bone Marrow Transplantation (Transplantation, Bone Marrow) 02/2014 - 04/2003
2	Immunotherapy 03/2022 - 02/2019
2	Aftercare (After-Treatment) 05/2019 - 05/2019